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The importance of collecting and using race and related data responsibly for health system improvement has been highlighted by communities, human rights advocates, equity researchers and other groups advocating for anti-racist research. To address these calls to action, ICES consulted with members of the public, external health equity experts, as well as internal staff, scientists and senior leaders to develop a Guidance Document and Framework for Anti-Racist Approaches to Research and Analytics. The aims of this Guidance Document and Framework are to outline organizational strategies to help implement anti-racist and anti-oppressive practices, support appropriate use of race and related data at ICES, prompt scientists and research teams to consider the role of systemic racism and other forms of oppression in perpetuating health inequities and support communities to access impactful research that is responsive to their needs and priorities.